The Thoracic Society of Australia & New Zealand
1998 Annual Scientific Meeting - Adelaide, March 15-18

SCIENTIFIC PROGRAM

Lung Cancer SIG Satellite Meeting

March 14-15, 1998

Objectives:

• To review current knowledge of
  • biology of lung cancer, including its application to diagnosis and treatment
  • screening strategies
  • new treatment modalities
  • optimal treatment of lung cancer
• To develop and endorse Australian guidelines for the diagnosis and treatment of lung cancer
• To develop a framework for Australian multicentre trials for the treatment of lung cancer

Saturday March 14th 1998

Session 1 Meeting Room 10

Chair:Paul Zimmerman - Director, Thoracic Medicine, The Prince Charles Hospital, QLD

1430 Introduction

1440 The scope of the problem: epidemiology and cost
Raylene Bowman - Staff Specialist, Thoracic Medicine, Royal Brisbane Hospital, QLD

1450 Biology of lung cancer
Kwong Fong - Thoracic Medicine, The Prince Charles Hospital, QLD

1510 Screening for lung cancer
Lou Irving - Department of Respiratory Medicine, Austin & Repatriation Medical Centre, VIC

1540 Advances in imaging, including the role of PET scanning
Phil Costello - Professor of Radiology, The Queen Elizabeth Hospital, SA

1600 Current practice in the treatment of lung cancer
David Ball - Lung Clinic, Peter MacCallum Cancer Institute, VIC

1620 Aims of treatment in lung cancer trials
Michael Millward - Peter MacCallum Cancer Institute, VIC

1640 Assessment of quality of life of patients with lung cancer
Francis Parnis - Medical Oncologist, Ashford Cancer Centre, SA

1700 Panel Discussion

1730 Close

Sunday March 15th 1998

Session 2Non-Small Cell Lung Cancer Meeting Room 10

0900 Surgery as single modality treatment
Brian McCaughan - Thoracic Surgery, Royal Prince Alfred Hospital, NSW

0915 Radiation as single modality treatment
David Ball - Lung Clinic, Peter MacCallum Cancer Institute, VIC

0930 Curative treatment with combined modality therapy
Michael Boyer, - Medical Oncology, Royal Prince Alfred Hospital, NSW

Brian Burmeister - Queensland Radium Institute, QLD

0950 Combined therapy for extensive disease
Michael Boyer

Brian Burmeister

1015 Logistics of multicentre trials and pitfalls of guidelines
John Simes - NH & MRC Clinical Trials Centre, NSW

1040 Panel Discussion

1100 Morning Tea

Session 3

1130 - 1230 hrs:Workshop Sessions

Groups 1-6

Guidelines

1. Staging of non-small cell cancer - what is essential and what is optimal?
2. Treatment of stage 3A non-small cell lung cancer
3. Treatment of advanced non-small cell lung cancer - multi-centre trials
4. Registry of lung cancer patients
5. Biological factors, eg tumour size, molecular markers and their influence on prognosis
6. Treatment of 3B cancer
7. Treatment of stage 4 cancer

1300 Lunch Meeting Room 11

Session 4

1345 Group reports

Summary of guidelines

Clinical trials

1500 The implementation of clinical guidelines

1530 The implementation of clinical trials

1600 Close of meeting

Sunday,15 March

0900 - 1030 hrs

Sym 1 Respiratory Nurses Symposium: Changes and Challenges

Meeting Room 1

Chair:Kate Stevens - Clinical Nurse Consultant, Women's and Children's Hospital, SA

0900 Welcome
Felicity Whitehead - Co-ordinator, Educational Unit, Respiratory Medicine, Alfred Hospital, VIC

0905 Evidence-based practice - where is it taking us?
Georgie Stamp - Senior Research Fellow, University of South Australia

0935 A breath of fresh air
Philip Darbyshire - Professor,Research and Practice Development Unit, Women's and Children's Hospital, Adelaide

1030 - 1100 hrs COFFEE Foyer 5

Oral 1 ORAL PRESENTATIONS Meeting Room 1

1100 - 1300 hrs

Chair:Kath McGregor - Nurse Manager Specialist, Respiratory Medicine, Green Lane Hospital, NZ

1100 HOSPITAL AND OUTREACH TEAMS WORKING TOGETHER FOR BETTER PATIENT OUTCOMES
J Ross, H McGrane [O1]

1120 COMPUTERISED MONITORING SYSTEM FOR PATIENTS ON HOME OXYGEN THERAPY
NA Heron, JR Wheatley [O2]

1140 MOTIVATION TOWARDS COOPERATION: QUALITY OF LIFE IMPLICATIONS FOR SELF - MANAGEMENT OF ADULTS WITH ASTHMA
C Partridge, A Reynolds, M Cesato, R Scicchitano [O3]

1200 PREVENTING TRANSMISSION OF RESPIRATORY PATHOGENS BY RESPIRATORY FUNCTION TESTING EQUIPMENT: AN APPROACH TO MINIMISING RISK IN THE ABSENCE OF DATA
L Gilroy, N Spearing, S Bowler [O4]

1220 ROLE OF A CLINICAL MANAGEMENT TEAM FOR ASTHMA
R Reilly [O5]

1240 SA HEALTHPLUS - THE ROLE OF SERVICE CO-ORDINATOR IN CO-ORDINATING CARE FOR PEOPLE WITH COPD/ASTHMA IN WESTERN ADELAIDE
D Kroemer, RRuffin, P Del Fante, C Caust, B Smith, P Conroy, M Battersby, C Grossman, L Russell, B Freeling, H Gilbert, E Kropf, C Hurley, P Bennett, H Dickman, J Noone [O6]

1300 - 1400 LUNCH Hall D

1300 Posters

THE EFFECT OF RESPIRATORY NURSE HOME INTERVENTION ON HOSPITALISATION OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
P Bennett, R Ruffin, B Smith, A Southcott, P Del Fante, R Adams, D Allan, G Roberts [P1]

SA HEALTH PLUS - CO-ORDINATING CARE FOR PEOPLE WITH COPD/ASTHMA IN WESTERN ADELAIDE.
D Kroemer, R Ruffin, P Del Fante, C Caust, B Smith, P Conroy, M Battersby, C Grossman, L Russell, B Freeling, H Gilbert, E Kropf, C Hurley, P Bennett, H Dickman, J Noone [P2]

1400 BUSINESS MEETING

Chair:Sheree Smith - Lecturer, Faculty of Health, Queensland University of Technology, QLD

1400 Research objectives and 1999 Conference discussion

1430 Standards of respiratory nursing practice and standards of advance practice

1450 Closing remarks
Sheree Smith - Lecturer, Faculty of Health, Queensland University of Technology, QLD

1500 Close

1630 - 1830 hrs Hall B

1630 Welcome by the President
Christopher Clarke - President, TSANZ

1635 The Australian Lung Foundation Awards

Chair:Bob Edwards - Chairman, Australian Lung Foundation

The Australian Lung Foundation/ Astra Career Development Award
Dr Darryl Knight - Senior Scientist, The Asthma and Allergy Research Unit, Department of Medicine, The University of Western Australia

The Australian Lung Foundation/ Boehringer Ingelheim Chronic Airflow Limitation Research Fellowship
Dr Xiang Ping Zeng - Senior Research Officer, Lung Research Laboratory, Department of Thoracic Medicine, Royal Adelaide Hospital

The Australian Lung Foundation/ Ludwig Engel Grant-in-Aid for Physiological Research
Dr Karen Waters - Clinical Senior Lecturer, New Children's Hospital, Sydney University

The Australian Lung Foundation / Dust Diseases Board of New South Wales Award

1998 Recipient: To be announced

The Australian Lung Foundation/ SensorMedics Travel Scholarships

1998 Recipients: To be announced

1710 SOCIETY MEDAL PRESENTATION and ACCEPTANCE

1730 WUNDERLY ORATION

Doctors for the new millennium: new dogs, new tricks
Professor Nicholas Saunders - Dean, School of Medicine, The Flinders University of South Australia

1830 - 2000 hrs WELCOME RECEPTION Exhibition Hall

Monday 16 March

0715 - 0815 hrs BREAKFAST SESSIONS

B 1 Pearls and pitfalls in cardiopulmonary exercise testing (CPET) Meeting Room 6
Idelle Weisman - Director, Department of Clinical Investigation, William Beaumont Army Medical Centre, USA

Objectives: participants will be able to:

• Recognise common pitfalls encountered during CPET and their impact on interpretation and clinical management
• Use helpful tips in methodology, protocols and interpretation of CPET
• Appreciate how the extensive amount of information obtained during CPET can be reasonably approached and meaningfully applied in clinical decision making

Chair:Sean Homan - The Queen Elizabeth Hospital, SA

B 2 Practical issues in lung transplantation Meeting Room 4
Trevor Williams - Transplant Unit, Alfred Hospital, Prahran, VIC

Objectives: The session will:

• Update practising thoracic physicians in the practical issues in the management of long term survivors of lung transplantation

Chair:Anne Marie Southcott - The Queen Elizabeth Hospital, SA

B 3 Multi-modal approach to non-small cell carcinoma of the lung Meeting Room 5
Ian Olver - Director, Medical Oncology, Royal Adelaide Hospital, Adelaide, SA

Objectives: The session will focus on:

• Evaluating the end-points of response, survival, and quality of life in patients treated for non-small cell carcinoma of the lung.
• Discuss the usefulness of therapy and who should be treated

Chair:Brian Smith - The Queen Elizabeth Hospital, SA

B 4 Evidence-based review of the asthma management plan Meeting Room 3
Peter Gibson - Staff Specialist Respiratory Medicine, John Hunter Hospital, NSW

Jenni Coughlan - Project Officer, National Asthma Campaign, NSW

Objectives:

• A presentation for discussion on the project methodology, research questions, availability of evidence from randomised controlled trials, and use of the Cochrane Airways Group database

Chair:Raffaele Scicchitano - Royal Adelaide Hospital, SA

0830 - 1000 hrs PLENARY SESSION Hall B

Plen 1 The Frontiers: Gene Therapy

Chair:Mark Holmes - Royal Adelaide Hospital, SA

Introduction to gene therapy
Jeffrey Whitsett - Director, Division of Pulmonary Biology & Neonatology, Children's Hospital Medical Centre, USA

Objectives:

• To understand the design, use and biologic considerations underlying the use of viral vectors for gene transfer to the respiratory epithelium for cystic fibrosis and other lung diseases.

Gene therapy in malignancy
Bruce Robinson - Director of Research Development, Sir Charles Gairdner Hospital, WA Objectives:

• Review ways in which gene therapy is being used to treat cancer, focussing on potential cellular mechanisms of action.
• Discuss the concepts underlying gene therapy approaches in cancer, current approaches being used, their limitations and future strategies associated with cancer gene therapy

Gene therapy in cystic fibrosis
Jeffrey Whitsett

1000 - 1045 hrs COFFEE AND TRADE EXHIBITION Exhibition Hall

1045 - 1230 hrs PLENARY SESSION Hall B

Plen 2 YOUNG INVESTIGATOR AWARD

Chair:Lou Irving - Chair, Education and Research Subcommittee

1045 PRENATAL GLUCOCORTICOIDS IMPROVE LUNG FUNCTION BUT CAUSE STRUCTURAL ABNORMALITIES IN THE DEVELOPING SHEEP LUNG
KE Willet, AH Jobe, M Ikegami, J Newnham, P McMenamin, PD Sly [O7]

1100 OXYGEN DIFFUSION LIMITATION AND INADEQUATE HYPERVENTILATION RESULTS IN ARTERIAL HYPOXEMIA IN TRAINED CYCLISTS
A Rice, S Hopkins, A Thornton, H Greville, R Scicchitano, P Wagner, G Scroop, C Gore [O8]

1115 GLUCOCORTICOIDS INHIBIT PROLIFERATION, CYCLIN D1 EXPRESSION AND RETINOBLASTOMA PROTEIN PHOSPHORYLATION, BUT NOT MITOGEN-ACTIVATED PROTEIN KINASE ACTIVITY IN HUMAN CULTURED AIRWAY SMOOTH MUSCLE
DJ Fernandes, E Guida, V Kalafatis, T Harris, J Wilson, AG Stewart [O9]

1130 THE EXPRESSION OF ADHESION MOLECULES ON NEUTROPHILS IS UPREGULATED IN RESPIRATORY SYNCYTIAL VIRUS-INDUCED BRONCHIOLITIS
S-Z Wang, PK. Smith, M Lovejoy, JJ. Bowden, JH. Alpers, KD. Forsyth [O10]

1145 TREATMENT OF OBSTRUCTIVE SLEEP APNOEA USING A MANDIBULAR ADVANCEMENT SPLINT
A. Faniran,A.S. Mehta, R. Palmisano, J. Qian, M. Darendeliler, P. Petocz, P. Cistulli [O11]

1200 SKELETAL MUSCLE PATHOPHYSIOLOGY IN SUBJECTS WITH SEVERE COAD
JM Morton, MJ McKenna, MF Carey, SF Fraser, G Snell, JA Parkin, M Rabinov, JA Smith, DS Esmore, TJ Williams [O12]

1230 - 1330 hrs LUNCH Exhibition Hall

SIG BUSINESS MEETINGS Venues to be announced

1330 - 1530 hrs CONCURRENT SESSIONS

Sym 1 National Asthma Campaign Symposium Hall C

1330 Asthma in Schools: South Australian Initiatives

Objective:

• To outline the implementation of the national policy for asthma management in schools into a Statewide project.

John Alpers - Director, Respiratory Unit, Flinders Medical Centre, SA

Rima Staugas - Chief, Paediatric Medicine, Women's & Children's Hospital, SA

Debra Kay - Project Manager, Interagency Health Care, Dept of Education, Training and Employment,

SA

1415

Asthma Adherence - the Seventh Step

Objective:

• To highlight the importance of adherence (compliance) and the doctor/patient relationship in asthma management.

Chair:Christine Jenkins - Chair, National Asthma Campaign

Doctor/patient communication
Jill Cockburn - Head, Discipline of Behavioural Science Faculty of Medicine,University of Newcastle, NSW

Practical strategies
Susan Sawyer - Respiratory Paediatrician, Royal Children's Hospital, VIC

Oral 2 Lung Cancer SIG: Oral Presentations Meeting Room 1

Chair:Lou Irving - Department of Respiratory Medicine, Austin & Repatriation Medical Centre, VIC

1330 BRONCHOSCOPY AT A TEACHING HOSPITAL - INDICATIONS, COMPLICATIONS AND RESULTS
S Chapman, P Robinson [O13]

1345 IMMUNOHISTOCHEMISTRY IN SMALL CELL LUNG CANCER - POSITIVE CEA IS ASSOCIATED WITH PROLONGED SURVIVAL
R Thomson, D Fielding, R Steele [O14]

1400 DETECTION OF TUMOUR-SPECIFIC MICROSATELLITE MARKERS IN THE BRONCHIAL MUCOSA AND PL1998 Annual Scientific MeetingA OF NON-SMALL CELL LUNG CANCER PATIENTS
BDMcCallum, H Ainsley, H Chalmers, A Frank. A Firgaira, A Morley [O15]

1415 THE RESULTS AND COMPLICATIONS OF 106 C.T GUIDED FINE NEEDLE PULMONARY BIOPSIES
L Rafter, W Oliver, K Fong, R Slaughter [O16]

1430 RB, P 16 AND P 53 IN NON-SMALL CELL LUNG CANCER
K Fong, PV Zimmerman, J. Geradts, R. Maynard, J.D. Minna [O17]

1445 TIME TRENDS AND INFLUENCE OF GENDER ON HISTOLOGY OF BRONCHOGENIC CARCINOMA
L C Morgan, H E Peters, M J Peters [O18]

1500 ASBESTOS SUPRESSES SOMATIC INTRACHROMOSOMAL RECOMBINATION IN PERITONEAL MESOTHELIOMA
D Turner, A Rogers, D Henderson, P Sykes [O19]

Oral 3 Cystic Fibrosis SIG: Oral Presentations Meeting Room 2

Objectives: Participants will be able to :

• Assess the value of mucolytic therapy in the treatment of cystic fibrosis.
• Describe new advances in the therapy of cystic fibrosis.
• Understand the immunological and pathogenic mechanisms of airflow obstruction and their impact on survival.

Chairs:Colin Robertson and John Wilson

1330 Current status of mucolytic therapy in cystic fibrosis
Peter Bye - Department of Respiratory, Royal Prince Alfred Hospital, NSW

1400 The first 12 months of DORNASE ALFA in Australia
Susan Sawyer - Department of Thoracic Medicine, Royal Children's Hospital, VIC

1430 MECHANISM OF POLIDOCANOL ENHANCEMENT OF ADENOVIRAL AIRWAY GENE TRANSFERIN VIVO:ENHANCEMENT IS NOT CONTINGENT ON EPITHELIAL CELL DAMAGE
D Parsons, P Hopkins, BR Grubb, RC Boucher [O20]

1445 AIRWAY WALL REMODELLING IN CYSTIC FIBROSIS
V Olsen, X Li, J Rolland, JW Wilson [O21]

1500 NEUTROPHILS FROM CHILDREN WITH CYSTIC FIBROSIS DEMONSTRATE INCREASED RESPONSIVENESS TO IL-8 BUT NOT TO FMLP
S Brennan, P Rye, D Cooper, GA Stewart, PD Sly [O22]

1515 LUNG TRANSPLANT (LTX) WAITING LIST MORTALITY IN ADULTS WITH CYSTIC FIBROSIS (CF)
GI Snell, K Bennetts, A Griffiths, M Rabinov, TJ Williams [O23]

Oral 4 Sleep and Physiology SIG: Oral Presentations Hall B

Chairs:John WheatleyandMathew Naughton

1330 THE USE OF CPAP TO IMPROVE NEUROPSYCHOLOGICAL FUNCTION, SLEEPINESS AND HYPERTENSION IN SUBJECTS WITH MILD SLEEP APNOEA
M Barnes, D Houston, C Worsnop, A Neill, I Mykytyn, A Kay, J Trinder, N Saunders,

D McEvoy, R Pierce [O24]

1345 RESPONSES TO LOBELINE INJECTIONS IN CONTROL SUBJECTS AND PATIENTS WITH LUNG TRANSPLANTS
SC Gandevia, JE Butler, A Anand, MR Crawford, AR Glanville, AS Paintal,

JL Taylor, DK McKenzie, P Cistulli [O25]

1400 DISCHARGE PROPERTIES OF HUMAN DIAPHRAGM AND PARASTERNAL INTERCOSTAL SINGLE MOTOR UNITS DURING STANDING AND LYING
JE Butler, DK McKenzie, SC Gandevia [O26]

1415 PULMONARY HYPERTENSION IN AWAKE OBSTRUCTIVE SLEEP APNEA (OSA) PATIENTS IS ASSOCIATED WITH HEIGHTENED VASCULAR RESPONSIVENESS TO HYPOXIA, AND VASCULAR REMODELLING
D Sajkov, R McEvoy, TT Wang, A Bune, N Saunders [O27]

1430 OLDER MEN HAVE GREATER FALLS IN RESPIRATORY PUMP AND UPPER AIRWAY MUSCLE ACTIVITIES AT SLEEP ONSET THAN YOUNGER MEN
C Worsnop, A Kay, J Trinder, Y Kim, R Pierce [O28]

1445 LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN NON-HYPERCAPNIC CENTRAL SLEEP APNOEA
P Solin, MT Naughton [O29]

1500 DIAPHRAGM CONTRIBUTION TO TIDAL VOLUME IN PATIENTS WITH SEVERE CHRONIC AIRFLOW LIMITATION
RB Gorman, DK McKenzie, NB Pride, JF Tolman, SC Gandevia [O30]

1515 NASAL VENTILATION (PRESSURE PRESET) IN PATIENTS WITH CHEYNE-STOKES RESPIRATION AND CONGESTIVE HEART FAILURE
GN Willson, I Wilcox, AJ Piper, WE Flynn, M Norman, RR Grunstein, CE Sullivan [O31]

1530 - 1600 hrs COFFEE AND TRADE EXHIBITION Exhibition Hall

1600 - 1730 hrs MANNED POSTER VIEWING Exhibition Hall

NURSING

THE EFFECT OF RESPIRATORY NURSE HOME INTERVENTION ON HOSPITALIZATION OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
P Bennett, R Ruffin, B Smith, AM Southcott, P Del Fante, R Adams, D Allan, G Roberts [P1]

SA HEALTHPLUS - COORDINATING CARE FOR PEOPLE WITH COPD / ASTHMA IN WESTERN ADELAIDE
D Kroemer, R Ruffin, P Del Fante, C Caust, B Smith, P Conroy, M Battersby, C Grossman, L Russell, B Freeling, H Gilbert, E Kropf, C Hurley, P Bennett, H Dickman, J Noone [P2]

ASTHMA I

ASTHMA: GENETICS

SEGREGATION ANALYSIS USING GIBBS SAMPLING FOR QUANTITATIVE TRAITS RELATED TO THE ASTHMA PHENOTYPE
LJ Palmer, AL James, AW Musk, WOCM Cookson, PR Burton [P3]

POWER TO DETECT LINKAGE TO BINARY AND QUANTITATIVE ASTHMA-ASSOCIATED TRAITS USING SIB-PAIR METHODS
LJ Palmer, PR Burton, WOCM Cookson [P4]

POLYMORPHISMS IN THE TNF GENE CLUSTER AND ASTHMA
C Hayden, R Albuquerque, P Rye, L Palmer, P Burton, J Goldblatt, P LeSouëf [P5]

CC16: THE A38G POLYMORPHISM IS ASSOCIATED WITH AIRWAY RESPONSIVENESS AT ONE MONTH AND ASTHMA AT 6 YEARS IN CHILDREN UNSELECTED FOR ASTHMA
IA Laing, E Eber, CM Hayden, PJ Rye, NA Gibson, LJ Palmer, PR Burton, J Goldblatt,

PN LeSouëf [P6]

ASTHMA: EPIDEMIOLOGY

INFECTIONS IN EARLY CHILDHOOD AND RISK OF ATOPIC DISEASE
J Pekkanen, M Kajosaari, A Koivikko, A Soininen [P7]

DOES HEPATITIS B IN EARLY CHILDHOOD REDUCE THE RISK OF ASTHMA?
P Leadbitter, M Kimbell-Dunn, N Pearce, C Moyes [P8]

IgE LEVELS IN THE PREDICTION OF ATOPY: CORD BLOOD IgE VS SERUM IgE,

A 6 YEAR FOLLOW-UP
P.K. Judge, L.J. Palmer, I. Laing, P.Rye, N. Gibson, P. O'Keefe, S. Young, J. Arnott,

J Goldblatt, LI Landau, PN LeSouëf [P9]

AGE-SPECIFIC GENDER DIFFERENCES IN AIRWAY HYPERRESPONSIVENESS AND RECENT WHEEZE FROM CHILDHOOD INTO YOUNG ADULTHOOD
W Xuan, GB Marks, BG Toelle, JK Peat, G Berry, A Woolcock [P10]

DECLINE OF FEV₁OVER 17 YEARS IN ASTHMATIC SUBJECTS
J Panizza, A.L. James, G Ryan, KE Finucane [P11]

ASTHMA IN HUNTER AREA WOMEN
A Wilson, R Toneguzzi, T Miles, PG Gibson and Hunter Expert Advisory Group on Asthma [P12]

VALIDATION OF THE ISAAC VIDEO QUESTIONNAIRE (AVQ3.0) IN ADOLESCENTS FROM A MIXED ETHNIC BACKGROUND
RC Toneguzzi, PG Gibson, RL Henry, S Shah, A Wilson, H Mamoon, L Francis [P13]

DO SUNSPOTS INFLUENCE ASTHMA MORTALITY?
MCF Pain, MD Pain [P14]

THE EPIDEMIOLOGY OF ASTHMA AND THE HOUSE DUST MITE
PS Clarke [P15]

ASTHMA: CELLULAR MECHANISMS

PERSISTENT AIRWAY INFLAMMATION IN CHILDREN WITH CONTROLLED ASTHMA
PG Gibson, RL Henry, Y Cai, K Fakes [P16]

MUCOUS GLAND INFLAMMATION AND MUCUS PLUGGING IN ASTHMA
NG Carroll, S Mutavdzic, AL James [P17]

SUBEPITHELIAL AND SUBMUCOSAL COLLAGEN IN FATAL ASTHMA
K Lee, X Li, N Carroll, A James, JW Wilson [P18]

CYCLIC-AMP REGULATED CHLORIDE TRANSPORT ACROSS THE AIRWAY EPITHELIUM APPEARS NORMAL IN ASTHMA
PG Middleton [P20]

INTERLEUKIN-5 AND EOSINOPHIL CATIONIC PROTEIN PRODUCTION ARE NOT REDUCED BY AN OMEGA-3 ENRICHED DIET IN CHILDREN WITH EXISTING ASTHMA
JM Hughes, SJ Rimmer, CM Salome, L Hodge, D Liu-Brennan, D Pang, M Allman, AJ Woolcock, CL Armour [P21]

THE EFFECT OF SUPPLEMENTARY INHALED FLUTICASONE PROPIONATE (FP) SALMETEROL AND PLACEBO THERAPY ON BAL LYMPHOCYTE ACTIVATION IN ASTHMATICS ON LOW DOSE INHALED CORTICOSTEROIDS
C Ward, X H Bao, R Bish, X Li, B Orsida, T Bamford, J Wilson, F Thien, E H Walters [P22]

INTERINDIVIDUAL VARIABILITY IN ACTIVATION OF BECLOMETHASONE DIPROPIONATE IN HUMAN LUNG CYTOSOLIN VITRO
K Foe, DJ Cutler, KF Brown, JP Seale [P23]

ASSESSMENT OF RESPONSIVENESS TO CHOLINERGIC STIMULATION IN PIG AIRWAYS
P Gray, D Turner, H Mitchell [P24]
IN VIVORESPONSIVENESS TO ACETYLCHOLINE FOLLOWING CHRONIC OVALBUMIN EXPOSURE IN THE SENSITISED PIG
D Turner, P Gray, H Mitchell [P25]

COMPARATIVE EFFECTS OF 24-HOUR EXPOSURE TO LIVE AND KILLEDBORDETELLA PERTUSSISAND LIPOPOLYSACCHARIDE (LPS) ON LUNG FUNCTION IN PVG RATS
J Wale, F Petak, M Tulic-Williams, S Napoli, A McWilliam, P Sly [P26]

BACTERIAL INFECTION ALTERS THE PROFILE OF AN ALLERGIC RESPONSE IN PVG RATS
MK Tulic-Williams, JL Wale, PD Sly [P27]

ASTHMA: PHYSIOLOGY

LUNG FUNCTION IN A RANDOM SAMPLE OF NON-SMOKING NON-ASTHMATICS IN THE NZ POPULATION
S Lewis, W D'Souza, I Town, R Armstrong, N Pearce [P28]

MANNITOL CHALLENGE AS A DIAGNOSTIC TEST FOR ASTHMA. A COMPARISON WITH ISOCAPNIC HYPERVENTILATION OF DRY AIR (ISH) AND EXERCISE CHALLENGES
H Koskela, JD Brannan, SD Anderson, H-K Chan [P29]

INHALED CORTICOSTEROIDS REDUCE AIRWAY RESPONSIVENESS TO INHALED MANNITOL: A PILOT STUDY
JD Brannan, H Koskela, SD Anderson, H-K Chan [P30]

PERCEPTION OF METHACHOLINE INDUCED BRONCHOCONSTRICTION
C Salome, A Roberts, G Marks, A Woolcock [P31]

ASTHMATICS BREATHE ORO-NASALLY DURING AND AFTER ACUTE EXACERBATIONS
K Kairaitis, S Garlick, TC. Amis, J Wheatley [P32]

CHANGE IN LUNG VOLUME WITH CHANGE IN POSTURE FROM UPRIGHT TO SUPINE IS NOT RELATED TO CHANGES IN AIRWAY HYPERRESPONSIVENESS
LM Schachter, CM Salome, AM Roberts, FG Issa, CE Sullivan, AJ Woolcock [P33]

CYSTIC FIBROSIS

CYTOKINES AND INFLAMMATORY MEDIATORS AS INDICATORS OF ACUTE INFECTION IN CYSTIC FIBROSIS (CF)
JM Wolter, RL Rodwell, S Bowler, JG McCormack [P34]

AIRWAY INFLAMMATION DOES NOT IMPROVE AFTER TREATMENT WITH AEROSOLISED DEOXYRIBONUCLEASE IN CYSTIC FIBROSIS
R Henry, P Gibson, K Carty, Y Cai, L Francis [P35]

RESPIRATORY RESPONSES TO UNSUPPORTED UPPER LIMB EXERCISE IN CYSTIC FIBROSIS
J Alison, P Bye [P36]

THE EFFECT OF MRSA ANDBURKHOLDERIA CEPACIAON DECLINE IN LUNG FUNCTION IN CYSTIC FIBROSIS
J Bartolo, M Conron, L Francis, X Li, JW Wilson [P37]

ADULT-DIAGNOSED CYSTIC FIBROSIS: PROGNOSIS AND THORACIC FINDINGS
JP Scott, JP Utz [P38]

HOME INTRAVENOUS ANTIBIOTIC THERAPY AND QUALITY OF LIFE IN ADULT CYSTIC FIBROSIS (CF)
R Moore, I Story, J Wilson, J Douglass [P39]

OCCUPATIONAL AND ENVIRONMENTAL LUNG DISEASE

CUMULATIVE EXPOSURE TO CROCIDOLITE AND RADIOLOGICAL ABNORMALITIES IN PREVIOUS RESIDENTS OF WITTENOOM
AW Musk, NH de Klerk, H Vu, J Hansen, SC Pang, MST Hobbs [P40]

ARE NEW INDOOR NITROGEN DIOXIDE GUIDELINES NEEDED?
B Smith, M Nitschke, R Ruffin, L Pilotto, D Pisaniello, M Abramson [P41]

RESPIRATORY SYMPTOMS IN NEW ZEALAND FARMERS
M Kimbell-Dunn, L Bradshaw, T. Slater, R Erkinjuntti-Pekkanen, D Fishwick, N Pearce [P42]

LONG-TERM OUTCOME OF FARMER'S LUNG
R Erkinjuntti-Pekkanen J Kokkarinen, H Rytkonen, H Tukiainen, EO Terho [P43]

OCCUPATIONAL RESPIRATORY SYMPTOMS IN NEW ZEALAND HAIRDRESSERS
T Slater, L Bradshaw, M Kimbell-Dunn, R Erkinjuntti-Pekkanen, S Cheng, D Fishwick,N Pearce [P44]

INFECTIOUS DISEASES AND TUBERCULOSIS

FULMINANT PSITTACOSIS REQUIRING MECHANICAL VENTILATION AND DEMONSTRATING SEROLOGICAL CROSS-REACTIVITYBETWEEN LEGIONELLA LONGBEACHAEANDCHLAMYDIA PSITTACI
R Soni, PJ Seale [P45]

PROTECTED BRUSH SPECIMENS ARE OF LIMITED USE IN OBTAINING A MICROBIOLOGICAL DIAGNOSIS FOR PATIENTS WITH PNEUMONIA
LC Morgan, MJ Peters, T Gottlieb, J Rutland [P46]

DIAGNOSIS 0F FUNGAL PNEUMONIA IN HAEMATOLOGICAL MALIGNANCIES
DM Smallwood, J Szer, JM. Vincent, MA Slavin [P47]

CYTOLOGICAL PROFILE IN BRONCHOALVEOLAR LAVAGE (BAL) FLUID OF HIV POSITIVE PATIENTS WITH PULMONARY INFECTION
N Wang, M Tamm, P Dalquen, M Soler, C Bolliger,, AP Perruchoud [P48]

THE CLINICAL UTILITY OF POLYMERASE CHAIN REACTION FOR THE DETECTION OFPNEUMOCYSTIS CARINIIUSING A CLINICAL DIAGNOSIS AS THE GOLD STANDARD
GW Waterer, A Giele, NJ Lavis, ID Kay, S Palladino, MA French, R Wilson, CH Heath, SA Mallal [P49]

PRELIMINARY DATA POINTING TOWARDS THE ENDPOINT OF A ËCUREÍ FORM. TUBERCULOSIS- A HYPOTHESIS
JA Streeton [P50]

A ROLE FOR SURGERY IN THE MANAGEMENT OF MULTIDRUG-RESISTANT TUBERCULOSIS: TWO CASE REPORTS
TD Robinson, D Barnes [P51]

RETROSPECTIVE REVIEW OF BCG ADVERSE REACTIONS IN SA 1986 -1997
K van Roekel, RA Stapledon, AT Thornton, M Gold [P52]

DUAL SKIN TEST STUDY COMPARING TUBERCULIN AND AVIAN PPDS IN UNVACCINATED SOUTH AUSTRALIAN SCHOOLCHILDREN
RA Stapledon, AT Thornton, JL Kilov, PC Robinson, R Antic, D Roder, K van Roekel [P53]

INFECTIONS WITHMYCOBACTERIUM AVIUM INTRACELLULARE(MAC) CAUSE SIGNIFICANT MORBIDITY AND MORTALITY IN IMMUNOCOMPETENT PATIENTS IN WESTERN AUSTRALIA
E Gabbay, D Cameron, Q Summers, R Tarala [P54]

1730 - 1900 hrs ALF WINE TASTING The Glasserie

1900 hrs COCHRANE COLLABORATION DINNER Meeting Room 10

1930 hrs ASTRA NIGHT

TUESDAY 17 March

0715 - 0815 hrs BREAKFAST SESSIONS

B 5 Application of spiral CT to diagnosis of pulmonary embolus Meeting Room 10
Philip Costello - Professor of Radiology, The Queen Elizabeth Hospital, Woodville, SA Objectives:

• To understand the principles of spiral CT and its application in the clinical diagnosis of patients with suspected pulmonary thrombo-embolic disease.

Chair:Brian Smith - The Queen Elizabeth Hospital, SA

B 6 Antibiotic treatment in the difficult cystic fibrosis patient Meeting Room 5
John Turnidge - Professor of Microbiology, Women's and Children's Hospital, Adelaide, SA

Objectives:

• To provide insight into the action, resistance, and selection of antibiotics in patients with cystic fibrosis.

Chair:Rima Staugas - Women's and Children's Hospital, SA

B 7 The effect of sleep fragmentation on daytime functioning Meeting Room 4
Neil Douglas - Professor, Respiratory and Sleep Medicine, University of Edinburgh

Objectives:

• To understand the relationships between induced transient sleep disruption and impairment of daytime function
• To examine the relationships between measures of spontaneous sleep disruption in patients and their daytime function
• To explore whether measures of sleep disruption can predict which patients with the sleep apnoea/hypopnoea syndrome respond to therapy

Chair:Anne Marie Southcott - The Queen Elizabeth Hospital, SA

0830 - 1000 hrs CONCURRENT SESSIONS

Sym 2 Symposium:The Frontiers:Options for End-Stage Lung Disease Hall B

Objectives:

• The session will provide participants with insights into the latest developments in the management of end-stage lung disease. The focus will be particularly on the surgical frontiers, but other issues and strategies will be addressed.

Chair:John Alpers - Flinders Medical Centre, SA

0830 Lung volume reduction surgery
Norbert Berend - Cardio-Thoracic Medicine, Royal North Shore Hospital, NSW

0855 Lung transplantation: advances, living donor transplant, xenotransplant
Trevor Williams - Transplant Services, Alfred Hospital, Prahran, VIC

0920 Case presentations and panel discussion

Sym 3 Symposium: Progress in Surfactant Therapy Hall C

Chair:James Martin - Women's and Children's Hospital, SA

0830 Use of surfactant in neonates
Jeffrey Whitsett - Director, Division of Pulmonary Biology & Neonatology, Children's Hospital Medical Centre, USA

Objectives:

• Understand the biology, structure and function of pulmonary surfactant and its use in neonates

0900 Long term outcomes in Neonatal Respiratory Distress Syndrome
Declan Kennedy - Senior Specialist, Women's and Children's Hospital, Adelaide, SA

Objectives:

• To examine the effects of prematurity and neonatal respiratory disease and its treatment on lung function in childhood.

0930 Use of surfactant in Adult Respiratory Distress Syndrome
Andrew Bersten - Senior Specialist, Intensive Care, Flinders Medical Centre, SA

Objectives:

• The role of surfactant dysfunction in the pathophysiology of ARDS, and the rationale for exogenous surfactant replacement therapy will be examined
• Data from current clinical trials will be presented, with a focus on timing, surfactant preparation, mode of delivery, dose and interaction with ventilatory strategies

Sym 4 Asthma SIG Symposium:PharmacologyMeeting Room 3

Objectives: participants will be able to:

• Understand the immunological mechanisms thought to underlie the asthmatic process
• Have insight into the development and application of new asthma drugs
• Be able to better use knowledge of the mechanism of drug action to improve asthma care

Chair:John Wilson - Department of Respiratory Medicine, Alfred Hospital, VIC

0830 Development of new asthma drugs
Gary Anderson - Department of Pharmacology, Melbourne University, VIC

0900 RHINOVIRUS INFECTION IN ASTHMATICS INCREASES NASAL IL-12 BUT NOT IL-10
A Ferreira, Z Williams, H Nell, EM van Schalkwyk, JR Joubert, PG Bardin [O33]

0915 A COMPARISON OF THE SAFETY, EFFICACY OF HIGH DOSE INHALED STEROIDS
N Berend [O32]

0930 INFLAMMATORY CYTOKINES INCREASE AIRWAY SMOOTH MUSCLE CONTRACTILITYIN VITRO.
AM Reynolds, MD Holmes, R Scicchitano [O34]

0945 SALMETEROL TACHYPHYLAXIS IMPROVES AFTER 6 MONTHS CONTINUOUS USE
F Thien, R Bish, S Gollant, J Walters, EH Walters [O35]

Sym 5 Sleep/Physiol SIG Symposium:Future Directions in the Management of Sleep Apnoea

Meeting Room 1

Objectives:

• To examine future trends in the investigation and treatment of sleep apnea.

Chair:David Hillman - Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, WA

0830 Future directions in the management of sleep apnoea
Neil Douglas: - Professor, Respiratory and Sleep Medicine, University of Edinburgh

0915 Mild to moderate sleep apnoea: is CPAP the answer?
Rob Pierce - Director, Department of Respiratory Medicine, Austin & Repatriation Medical Center, VIC

0940 Dental therapies: what are available? when to use?
Peter Cistulli - Sleep Disorders Centre, St George Hospital, NSW

Sym 6 Population Health SIG Symposium: Lung Disease in Australian Aborigines

Meeting Room 11

Objectives:

• To review the nature, importance and causes of pulmonary diseases amongst Aboriginal Australians.

Chair:Guy Marks and Antony Veale

0830 Introduction
Antony Veale - Department of Respiratory Medicine, The Queen Elizabeth Hospital, SA

0840 Pneumonia
Paul Torzillo - Department of Respiratory Medicine, Royal Prince Alfred Hospital, NSW

0900 Asthma
Allan James - Department of Respiratory Physiology, Sir Charles Gairdner Hospital, WA

0920 Normal Lung Function
John Thompson - Visiting Fellow, National Center for Epidemiology and Population Health, ACT

0940 Chronic Lung Disease
Antony Veale

1000 - 1045 hrs COFFEE AND TRADE EXHIBITION Exhibition Hall

1045 - 1230 hrs CONCURRENT SESSIONS

Sym 7 Symposium: Home Ventilation: Issues in Respiratory and Neuromuscular Disease Hall B

Objectives:

• To discuss indications for home ventilation (invasive and non invasive) in adults and children
• To discuss ethical concerns raised by the application of this technology
• To discuss techniques and cost associated with the use of this treatment

Chair:Don Campbell - Department of Respiratory Medicine, Austin & Repatriation Medical Centre, VIC

Ethics and choices
David Hart - Department of Respiratory Medicine, St Vincent's Hospital, VIC

Indications and outcomes
Ron Grunstein - Sleep Disorders Center, Royal Prince Alfred Hospital, NSW

Paediatric aspects
Karen Waters - New Children's Hospital , NSW

Initiating ventilator support and weaning from continuous ventilator support
David Berlowitz - Physiotherapist, Department of Respiratory Medicine, Austin & Repatriation Medical Centre, VIC

Costs and funding issues
Don Campbell - Department of Respiratory Medicine, Austin & Repatriation Medical Centre, VIC

Oral 5 Asthma SIG: Oral Presentations - Epidemiology Meeting Room 3

Chair:John Wilson - Department of Respiratory Medicine, Alfred Hospital, VIC

1045 LONG-TERM REDUCTION IN ASTHMA MORBIDITY FOLLOWING AN ASTHMA SELF-MANAGEMENT PROGRAMME
WJ D'Souza, H Te Karu, C Fox, M Harper, T Gemmell, M Ngatuere, K Wickens, J Crane, N Pearce, R Beasley [O36]

1105 QUALITY OF LIFE QUESTIONNAIRES IN ADOLESCENTS WITH ASTHMA: A PILOT STUDY
C Rutishauser, S Sawyer, G Bowes [O37]

1125 TRENDS IN HOSPITAL RE-ADMISSION FOR ASTHMA IN SOUTH AUSTRALIA
K McCaul, M Wakefield, J Alpers, A Heard, R Ruffin, R Staugas [O38]

1145 LONGITUDINAL PREDICTORS OF CURRENT ASTHMA, BRONCHIAL REACTIVITY AND ATOPY IN YOUNG ADULTS
M.Abramson, M.Bailey, S.C.Dharmage, J.Raven, A.Cheng, T.Mitakakis, J.Rolland, D.Guest, F.C.K.Thien, E.H.Walters [O39]

1205 LINKAGE ANALYSIS OF CHROMOSOME 11Q13 AND 5Q31-33 MARKERS TO ASTHMA-ASSOCIATED QUANTITATIVE TRAITS IN AN AUSTRALIAN SAMPLE OF NUCLEAR FAMILIES
LJ Palmer, SE Daniels, GK Tay, PJ Rye, NA Gibson, WOCM Cookson, J Goldblatt, PR Burton, PN LeSouëf [O40]

Sym 8 Cochrane Symposium Meeting Room 1

Objectives:

• To review current work for a range of topics by the Cochrane Collaboration Airways Group members

Chair:Peter Gibson - Respiratory Medicine Unit, John Hunter Hospital, NSW

1045 Introduction
Steve Milan and Peter Gibson

1050 Corticosteroids in acute exacerbations of COPD
Richard Wood-Baker - Department of Respiratory Medicine, Royal Hobart Hospital, TAS

1105 METHOTREXATE IS A STEROID SPARING AGENT IN ADULT ASTHMA: A SYSTEMATIC REVIEW
HR Davies, LG Olson, PG Gibson [O41]

1120 ASTHMA EDUCATION WITHOUT SELF MANAGEMENT IS EFFECTIVE ONLY IN HIGH RISK ADULTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
P Gibson, J Coughlan, A Wilson, M Hensley, M Abramson, A Bauman, H Walters [O42]

1135 Mucolytics in bronchiectasis
Jo Cranston - Department of Respiratory Medicine, Flinders Medical Centre, SA

1150 Home respiratory nursing care in COPD
Brian Smith - Department of Respiratory Medicine, The Queen Elizabeth Hospital, SA

1205 Allergen immunotherapy in asthma
Michael Abramson - Department of Social and Preventative Medicine, Monash Medical School, VIC

1220 Summary:
Steve Milan - UK Cochrane Airway Group, St George's Hospital, London,UK

Peter Gibson - Respiratory Medicine Unit, John Hunter Hospital, NSW

1230 - 1330 : Revman demonstration bySteve MilanMeeting Room 1

Oral 8 Paediatric SIG Oral Presentation: Infant Lung Function Hall C

Chairs: Phil Robinson and Gus Cooper

1045 Infant lung function overview
Peter Sly - Institute of Child Health, WA

1115 RESPIRATORY MECHANICS IN NORMAL INFANTS USING LOW-FREQUENCY FORCED OSCILLATIONS
G Hall, F Petak, N Dore, MJ Hayden, Z Hantos, P D.Sly [O43]

1130 MEASUREMENTS OF NITRIC OXIDE USING THE SINGLE-BREATH TECHNIQUE WITH POSITIVE EXPIRATORY PRESSURE IN INFANTS
JH Wildhaber, N Dore, T Uhlig, S Stick [O44]

1145 MATERNAL BUT NOT FETAL GLUCOCORTICOID TREATMENT CAUSES GROWTH RETARDATION IN PRETERM SHEEP
K Willet, M Ikegami, A Jobe, J Newnham, G Hall, J Pillow, P Sly [O45]

1200 AIRWAY WALL THICKNESS AND SMOOTH MUSCLE AREA IN INFANT LUNGS
K McKay, B Wiggs [O46]

1215 LUNG FUNCTION IN CHILDREN OF VERY LOW BIRTH WEIGHT AT ELEVEN YEARS OF AGE
D Kennedy, L Edward, D Bates, AJ Martin, S Nobbs, R Haslam, A McPhee, RE Staugas [O47]

1230 - 1330 hrs LUNCH Exhibition Hall

SIG BUSINESS MEETINGS Venues to be announced

1330 - 1500 hrs MANNED POSTER VIEWING AND COFFEE Exhibition Hall

CELL BIOLOGY

ELEVATED IL-8 AND NEUTROPHILS IN BAL FROM LUNG TRANSPLANT RECIPIENTS WITH AND WITHOUT BRONCHIOLITIS OBLITERANS SYNDROME
N Wang, L Zheng, C Ward, BE Orsida, T Kotsimbos, EH Walters, TJ Williams, GI Snell [P55]

HAEMOSIDERIN-LADEN MACROPHAGES (HLM) IN BAL POST LUNG TRANSPLANT (LTX)
D Reid, R Krishnaswamy, L Zheng, T Williams, G Snell, E H Walters, C Ward [P56]

BRONCHOALVEOLAR LAVAGE CELL PROFILES IN STABLE LUNG TRANSPLANT RECIPIENTS OVER TIME
H Whitford, L Zheng, C Ward, T Williams, T Kotsimbos, EH Walters, G Snell [P57]

THE EFFECT OF 3 MONTHS TREATMENT WITH HIGH DOSE INHALED FLUTICASONE PROPIONATE (FP) ON AIRWAY INFLAMMATION IN LUNG TRANSPLANT RECIPIENTS
H Whitford, B Orsida, L Zheng, C Ward, T Kotsimbos, T Williams, EH Walters,, G Snell [P58]

DEXAMETHASONE IS EFFECTIVE AT BLOCKING OSMOTICALLY STIMULATED ICLN, A CHLORIDE CHANNEL INVOLVED IN CELL VOLUME REGULATION
LT Rodwell, M Gschwentner, A Schmarda, SD Anderson, M Paulmichl [P59]

ATOPIC ASTHMATIC SERUM INCREASES PRODUCTION OF MATRIX PROTEINS FROM HUMAN AIRWAY SMOOTH MUSCLE CELLS IN CULTURE
PRA Johnson, PA Underwood, S Carlin, CL Armour, JL Black [P60]

INTERLEUKIN-1b(IL-1b) AND TUMOUR NECROSIS FACTOR-a(TNF-a) STIMULATE HUMAN AIRWAY SMOOTH MUSCLE CELLS TO RELEASE GRANULOCYTE MACROPHAGE-COLONY STIMULATING FACTOR (GM-CSF)
MB Sukkar, PRA Johnson, JM Hughes, CL. Armour [P61]

SALBUTAMOL MODULATES PROLIFERATION, RETINOBLASTOMA PROTEIN PHOSPHORYLATION AND CYCLIN D1 PROTEIN LEVELS, BUT NOTmRNA LEVELS IN THROMBIN-STIMULATED HUMAN AIRWAY SMOOTH MUSCLE CELLS
T Harris, V Kalafatis, E Guida, L Schachte, JW Wilson, AG Stewart [P62]

FACTORS INFLUENCING THE ACTIVITY OF GLUTAMYLCYSTEINE SYNTHETASE IN A549 AIRWAY EPITHELIAL CELLS IN CULTURE
S Ray, P Thompson [P63]

CONSTITUTIVE EXPRESSION OF THE INDUCIBLE ISOFORM OF CYCLOOXYGENASE (COX-2) IN HUMAN AIRWAY EPITHELIUM
N Watkins, D Peroni, D Knight, M Garlepp, P Thompson [P64]

THE ANTIOXIDANTS GLUTATHIONE AND N-ACETYLCYSTEINE ENHANCE APOPTOSIS OF HUMAN NEUTROPHILS
NLA Misso, CD Peacock, DN Watkins, PJ Thompson [P65]

INDUCTION OF SUBSTANCE P (SP) RELEASE AND NK-1 RECEPTOR (NK-1R) GENE EXPRESSION BY LEUKEMIA INHIBITORY FACTOR (LIF) IN TRACHEAL EXPLANTS
DA Knight, D Zhou, RR Schellenberg, TR Bai [P66]

MODULATION OF APOPTOSIS AND SUBSTANCE P (SP) INDUCED EOSINOPHIL CHEMOTAXIS BY LEUKEMIA INHIBITORY FACTOR
DA Knight, X Zheng, CD Peacock, PJ Thompson, TR Bai [P67]

IN VITRO EFFECTS OF GLUCOCORTICOSTEROIDS ON CYTOKINE PRODUCTION AND T-CELL ACTIVATION - A WHOLE BLOOD CYTOKINE ASSAY
S Hodge, P Han, R Flower, G Hodge [P68]

EFFECT OF GLUCOCORTICOSTEROIDS ON APOPTOSIS OF LEUCOCYTE SUBSETS - A COMPARISON BETWEEN CULTURED MONONUCLEAR CELLS AND WHOLE BLOOD
G Hodge, S Hodge, R Flower, P Han [P69]

PERSISTENT VACCINIA VIRUS-INTERLEUKIN 2 (VV-IL2) GENE EXPRESSION IN MALIGNANT MESOTHELIOMA (MM) DESPITE EVIDENCE OF ANTI-VIRAL IMMUNITY
S Mukherjee, T Haenel, R Himbeck, M Epton, RA Lake, G Harnett, P Phillips, S Morey, D Smith, I Ramshaw, J Davidson, W Musk, B Robinson [P70]

EXPRESSION OFa-ANDb-DEFENSINS IN INFLAMMATORY CELLS AND EPITHELIUM FROM HUMAN AIRWAYS
XP Zeng, M Holmes, R Scicchitano [P71]

NITRIC OXIDE

EXHALED NITRIC OXIDE LEVELS IN A GENERAL POPULATION SAMPLE - DISTRIBUTION, REPEATABILITY AND EFFECT OF AMBIENT LEVELS
A Roberts, C Salome, N Brown, J Dermand, A Woolcock [P72]

EXHALED NITRIC OXIDE LEVELS IN A GENERAL POPULATION SAMPLE - RELATION TO AIRWAY HYPERRESPONSIVENESS, SYMPTOMS AND ATOPY
C Salome, A Roberts, N Brown, J Dermand, A Woolcock [P73]

EXPIRED NITRIC OXIDE LEVELS IN HEALTHY 7-11 YEAR OLD CHILDREN:UNEXPECTED ASSOCIATION WITH POSITIVE SKIN PRICK TESTS
P Franklin, S Stick ` [P74]

EXHALED NITRIC OXIDE LEVELS ARE REPEATABLE, REPRODUCIBLE AND REFLECT NO LEVELS IN THE LOWER RESPIRATORY TRACT
E Gabbay, AJ Fisher, T Small, A Leonard, PA Corris [P75]

A CROSS-SECTIONAL STUDY OF EXHALED NITRIC OXIDE LEVELS FOLLOWING LUNG TRANSPLANTATION
E Gabbay, AJ Fisher, T Small, JH Dark, PA Corris [P76]

EXHALED NITRIC OXIDE AS A MARKER OF ACUTE REVERSIBLE GRAFT DYSFUNCTION FOLLOWING LUNG TRANSPLANTATION
E Gabbay, AJ Fisher, T Small, S Doig, JH Dark, PA Corris [P77]

NITRITE AS A POTENTIAL MARKER OF AIRWAY INFLAMMATION IN LUNG TRANSPLANT RECIPIENTS
RJ Ward, H Whitford, L Zheng, C Ward, J Taylor, G Snell, TJ Williams, EH Walters [P78]

NITRIC OXIDE (NO) LEVELS IN EXHALED AIR IN INTERSTITIAL LUNG DISEASE
UG Lalloo, Y Moodley, R Chetty [P79]

SLEEP AND CLINICAL PHYSIOLOGY

HYPOXIA DOES NOT IMPAIR INSPIRATORY RESISTIVE LOAD DETECTION ABILITY
RS Orr, P Catcheside, NA Saunders, RD McEvoy [P81]

MECHANISMS OF INSPIRATORY RESISTIVE LOAD DETECTION: INSIGHTS FROM A BREATH BY BREATH ANALYSIS
P Catcheside, RS Orr, NA Saunders, RD McEvoy [P82]

HYPERCAPNIA AUGMENTS THE VENTILATORY BUT NOT THE HEART RATE RESPONSE TO REPETITIVE HYPOXIA IN AWAKE MALES
SG McNamara, N Edwards, CE Sullivan [P83]

CENTRAL SLEEP APNOEA AND CONGESTIVE HEART FAILURE FOLLOWING LUNG TRANSPLANTATION AND VAGAL DENERVATION
P Solin, GI Snell, TJ Williams, MT Naughton [P84]

EFFECT OF CYCLE-TIME ON THE SEQUELAE OF REPETITIVE HYPERCAPNIC-HYPOXIA IN PIGLETS
KA Waters, KD Tinworth [P85]

UPPER AIRWAY MUCOSAL SENSATION ASSESSED BY LASER-EVOKED VERTEX POTENTIALS
R Parikh, SJ Cala, CL Lim, L Collins, JR Wheatley [P86]

THE EFFECT OF OBSTRUCTIVE SLEEP APNOEA SYNDROME ON NEUROCOGNITIVE FUNCTIONING IN CHILDREN AGED 6-10 YEARS
JD Kennedy, S Blunden, J Martin, K Lushington [P87]

SLEEP STAGE SHIFTS AND REPETITIVE WAKEFULNESS: RELATIONSHIP TO WORKING MEMORY DECREMENT
D.Joffe, G. Marshall, G. Herkes, N.Berend [P88]

DAYTIME PREDICTORS OF SEVERITY OF SLEEP HYPOVENTILATION IN PATIENTS WITH MUSCULAR DYSTROPHY
C Hukins, D Hillman [P89]

A PROSPECTIVE EVALUATION OF MANDIBULAR ADVANCEMENT SPLINTS IN PATIENTS WITH OBSTRUCTIVE SLEEP APNOEA
IA Yang, RA O'Sullivan, MH Spratley, GI Jorgensen, PV Zimmerman [P90]

NON-INVASIVE VENTILATORY SUPPORT: CLINICAL EXPERIENCE WITH BI-LEVEL PRESSURE PRESET DEVICES
WE Flynn, AJ Piper, GN Willson, CE Sullivan [P91]

VENTILATORY ASSISTANCE IN PATIENTS WITH NOCTURNAL HYPOVENTILATION SYNDROMES - EFFECTS ON VENTILATION DURING SLEEP
AJ Piper, H Becker, W Flynn, SG McNamara, M Norman, G Willson, CE Sullivan [P92]

ARM LOADING ALTERS RIB CAGE/ABDOMINAL MOVEMENT AND RESPIRATORY MUSCLE RECRUITMENT IN NORMAL SUBJECTS
J Alison, J Regnis, S Cala, C Moriarty, R Freed, PTP Bye [P93]

NON-INVASIVE ESTIMATION OF DIAPHRAGM LENGTH IN PATIENTS WITH SEVERE CHRONIC AIRFLOW LIMITATION AND EMPHYSEMA
JF Tolman, DK McKenzie, RB Gorman, NB Pride, SC Gandevia [P94]

IMPULSE OSCILLOMETRY: THE DETECTION OF PARADOXICAL BRONCHODILATOR RESPONSE
MG Rozee, AJ Crockett, JH Alpers [P95]

INTER-LABORATORY VARIABILITY IN THE MEASUREMENT OF LUNG FUNCTION
PA Guy, JJ Pretto, PD Rochford [P96]

EXTERNAL NASAL DILATOR STRIPS ALTER NASAL AIRWAY PRESSURE-FLOW DYNAMICS DURING EXERCISE IN SOME NORMAL SUBJECTS
SR Garlick, JM Gehring, TC Amis, JR Wheatley [P97]

EXTERNAL NASAL DILATOR STRIPS INFLUENCE ROWING PERFORMANCE IN ELITE ATHLETES
J Kirkness, TC Amis, M Seto-Poon, K Graham, E Stilwell, J Wheatley [P98]

EXTERNAL NASAL DILATOR STRIPS DECREASE THE FLOW-RESISTIVE WORK OF NASAL BREATHING DURING EXERCISE
JM Gehring, TC Amis, SJ Cala, JR Wheatley [P99]

EXTERNAL NASAL DILATOR STRIPS INCREASE MAXIMUM INSPIRATORY FLOW RATES
EM Di Somma, TC Amis, SN West, JR Wheatley [P100]

NASAL DILATOR STRIPS DELAY ONSET OF ORO-NASAL BREATHING DURING EXERCISE
M Seto-Poon, TC Amis, J Kirkness, J Wheatley [P101]

MAXILLARY SPORTS MOUTHGUARDS DO NOT IMPEDE ORAL ROUTE BREATHING
F Bacha, TC. Amis, E Di Somma, M Seto-Poon, K Isles, J Wheatley [P102]

LUNG VOLUME REDUCTION SURGERY

THE FIRST REPORT OF THE AUSTRALIAN LUNG FOUNDATION LUNG VOLUME REDUCTION SURGERY DATABASE
C Franklin, EH Walters, JA Smith, GI Snell [P103]

LUNG VOLUME REDUCTION SURGERY FOR EMPHYSEMA AT THE ALFRED HOSPITAL
GI Snell, J Morton, M Rabinov, D Esmore, TJ Williams, W Chin, EH Walters, C Franklin, JA Smith [P104]

LUNG VOLUME REDUCTION SURGERY: ADELAIDE EXPERIENCE
S Porter, R Ruffin, M Peacock, AM Southcott, J Pfitzner [P105]

LUNG VOLUME REDUCTION SURGERY AT THE QUEEN ELIZABETH HOSPITAL: HEALTH OUTCOMES & THE POTENTIAL IMPACT ON THE HOSPITAL BUDGET
M Hopps, S Porter, R Ruffin, B Smith, M Peacock [P106]

TRANSFER FACTOR CORRECTED FOR VENTILATED LUNG VOLUME IS REDUCED BY LUNG VOLUME REDUCTION SURGERY
S Homan, L Saccoia, A Herrero, D Figurski, S Porter, M Peacock, R Ruffin, AM Southcott [P107]

VOLUME OF LUNG VENTILATED IS INCREASED FOLLOWING LUNG VOLUME REDUCTION SURGERY
S Homan, L Saccoia, A Herrero, D Figurski, S Porter, M Peacock, R Ruffin, AM Southcott [P108]

IMAGING STUDIES IN EMPHYSEMA PREDICT PHYSIOLOGICAL DIFFERENCES IN PATIENTS PRESENTING FOR LUNG REDUCTION SURGERY (LRS)
M Conron, JA Smith, M Rabinov, C Franklin, EH Walters, GI Snell [P109]

IMPACT OF LUNG VOLUME REDUCTION SURGERY (LVRS) ON RESPIRATORY FUNCTION DURING SLEEP
H Whitford, M Naughton, EH Walters, G Snell [P110]

THE ASSESSMENT OF BOVINE PERICARDIAL STRIPS IN THE REDUCTION OF AIR LEAK FOLLOWING LUNG VOLUME REDUCTION SURGERY
H Crocker, M Peacock, J Pfitzner, R Ruffin [P111]

PAEDIATRICS

IS THE INCREASED RISK OF SIDS IN INFANTS EXPOSED TO NICOTINE DUE TO ABNORMALITIES OF RESPIRATORY DRIVE?
Y Ueda, SM Stick, PD Sly [P112]

LUNG DEPOSITION FROM A PRESSURISED METERED DOSE INHALER THROUGH A SPACER IN CHILDREN WITH ASTHMA
JH Wildhaber, H Janssens, F Pierart, N Dore, B Thompson, R Troedson, S Devadason,

P LeSouëf [P113]

AIRWAY INFLAMMATION IN CHILDREN WITH ACUTE ASTHMA
R Henry, MZ Norzila, K Carty, P Gibson [P114]

FOETAL GROWTH AND RISK OF ASTHMA AND ATOPY
A Gregory, I Doull, S Cheng, P Leadbitter, N. Pearce, R. Beasley [P115]

1500 - 1645 hrs CONCURRENT SESSIONS

Sym 9 Paediatric SIG Symposium: Hall B

Objectives:

• To review areas in paediatrics where there has been significant recent research activity
• To summarise the recent research in the area and to outline the impact on clinical practice

Chairs:Colin Robinson and James Martin

1500 Introduction and business meeting

1515 Aerosol deposition studies: their impact on clinical practice
Peter LeSouëf - University Department of Child Health, Princess Margaret Hospital for Children, WA

1545 Serology of respiratory tract infections
John Turnidge - Professor of Microbiology, Women's and Children's Hospital, Adelaide, SA

1615 Early inflammation in cystic fibrosis, 1998: what have we learned so far and where to in the next 5 years?
David Armstrong - Department of Thoracic Medicine, Royal Children's Hospital, VIC

Sym 10 Sleep SIG Symposium: Effectiveness and Cost-Effectiveness of Nasal CPAP Hall C

Objectives:

• To review evidence for the effectiveness and cost effectiveness of nasal CPAP

Chair:Bill Finucane - Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, WA

1500 The strengths and limitations of evidence-based medicine
Chris Silagy - Professor, Evidence-Based Care and General Practice, Flinders Medical Center, SA

1530 nCPAP: effectiveness and cost-effectiveness: the UK perspective
Neil Douglas - Professor, Respiratory and Sleep Medicine, University of Edinburgh, UK

1600 nCPAP: effectiveness and cost-effectiveness: the Australian Health Technology Advisory Council (AHTAC) report
Doug McEvoy - Director, Sleep Disorders Unit, Repatriation General Hospital, SA

Oral 9 Cell Biology SIG: Oral Presentations Meeting Room 1

Chair:Alistair Stewart - St Vincent's Hospital, VIC

1500 A DOMINANT NEGATIVE MUTANT OF PKC-ZINHIBITS GROWTH OF HUMAN AIRWAY SMOOTH MUSCLE (H1998 Annual Scientific Meeting) CELLS IN CULTURE
J Black, S Carlin, P Johnson, D Cook, L Carpenter, T Biden, P Poronnik [O48]

1515 CYTOKINE-MEDIATED MODULATION OF MITOGEN-STIMULATED DNA SYNTHESIS IN HUMAN CULTURED AIRWAY SMOOTH MUSCLE IS PREVENTED BY DEXAMETHASONE: ROLE OF ANTI-MITOGENIC EICOSANOIDS
R Vlahos, JW Wilson, AG Stewart [O49]

1530 IDENTIFICATION OF HETEROGENEOUS INTRACELLULAR SIGNALLING PATHWAYS SUBSERVING MITOGENESIS OF HUMAN AIRWAY SMOOTH MUSCLE
C Ravenhall, V Kalafatis, T Harris, P Vadiveloo, A Stewart [O50]

1545 MODULATION OF APOPTOSIS IN HUMAN PERIPHERAL BLOOD EOSINOPHILS BY AIRWAY EPITHELIUM-DERIVED INFLAMMATORY MEDIATORS
CD Peacock, NLA Misso, DN Watkins, PJ Thompson [O51]

1600 IMMUNOLOGICAL STUDIES OF RECOMBINANT OUTER MEMBRANE PROTEINS OFHAEMOPHILUS INFLUENZAE
MJ Epton, PJ Thompson, WR Thomas [O52]

1615 ONCOSTATIN M (OSM) SYNERGIZES WITH HOUSE DUST MITE (HDM) ALLERGEN AND INFLAMMATORY CYTOKINES TO INDUCE PGE₂RELEASE FROM EPITHELIAL CELLS
DA Knight, GA Stewart, DN Watkins, A Gurusinghe, PJ Thompson [O53]

1630 NEUTROPHILS AUGMENT DAMAGE TO RESPIRATORY EPITHELIAL CELLS INDUCED BY RESPIRATORY SYNCYTIAL VIRUS INFECTION
S-Z Wang, H Xu, A Wraith, JJ Bowden, JH Alpers, KD Forsyth [O54]

1700 hrs ANNUAL GENERAL MEETING Hall B

1930 hrs CONFERENCE DINNER Hall E

Award Presentation

TSANZ/ Allen & Hanburys Respiratory Research Fellowship

The Young Investigator Award

TSANZ Research Medal Award

Wednesday 18 March

0715 - 0815 hrs BREAKFAST SESSIONS

B 8 Palliative care issues for pulmonary patients Meeting Room 4
Mary Brooksbank - Director, Palliative Care, Royal Adelaide Hospital, Adelaide, SA

Objectives:

• To explore the broad issues surrounding terminal illness including the multiplicity of symptoms and multiple losses for patients and family.
• To examine the issues of facing death for the patient, family and doctor.

Chair:Raffaele - Royal Adelaide Hospital, SA

B 9 Pearls and pitfalls in cardiopulmonary exercise testing (CPET) Meeting Room 5
Idelle Weisman - Director, Department of Clinical Investigation, William Beaumont Army Medical Centre, USA

Objectives: participants will be able to :

• Recognise common pitfalls encountered during CPET and their impact on interpretation and clinical management
• Use helpful tips in methodology, protocols and interpretation of CPET
• Appreciate how the extensive amount of information obtained during CPET can be reasonably approached and meaningfuly applied in clinical decision making

Chair:Peter Allcroft - Repatriation Hospital, SA

B 10 Medical intervention in pleural disease Meeting Room 10
Peter Robinson - Senior Medical Consultant, Royal Adelaide Hospital, Adelaide, SA

Objectives: The session will provide participants with:

• A rational approach to diagnosis and management of pleural effusions and pleural masses
• The latest developments in the approach to medical intervention in pleural disease

Chair:Brian Smith - The Queen Elizabeth Hospital, SA

0830 - 1000 hrs PLENARY SESSION Hall B

Plen 3 The Frontiers: What is the Cost and Who Pays?

Objectives:

• To discuss the economics, ethics, and decision making process in the distribution of health resources

Chair:Christopher Clarke - President, TSANZ

Whither health care? The expenses and ethics of advancing the frontiers
Gavin Mooney - Professor of Health Economics, Sydney University, NSW

Community perspective on health care
Fran Baum - Professor, Community Health Research Unit, Flinders University, SA

The academic clinician perspective
Jeffrey Whitsett - Director, Division of Pulmonary Biology & Neonatology, Children's Hospital Medical Centre, USA

Who decides and how?
David Filby - Executive Director, Policy and Budget, Health Commission, SA

1000 hrs COFFEE AND TRADE EXHIBITION Exhibition Hall

1045 - 1230 hrs MANNED POSTER VIEWING Exhibition Hall

ASTHMA II

ASTHMA MANAGEMENT

ASTHMA MANAGEMENT IN GENERAL PRACTICE AFTER FIVE YEARS OF THE NATIONAL ASTHMA CAMPAIGN
C Mitchell, A Bauman, C Bridges-Webb, C Cooper, A Bhasale [P116]

THE ASTHMA MANAGEMENT PRACTICES OF AUSTRALIAN COMMUNITY PHARMACISTS
M Abramson, J Gattera, L Roller [P117]

A QUALITATIVE ANALYSIS OF PATIENT ADHERENCE WITH THE AUSTRALIAN ASTHMA MANAGEMENT PLAN
BG Toelle, SM Dunn, JK Peat [P118]

MEASUREMENT OF QUALITY OF LIFE IN CHILDREN AND ADOLESCENTS WITH ASTHMA
C Rutishauser, S Sawyer, G Bowes [P119]

THE QUALITY OF LIFE EFFECTS OF ALTERNATIVE INHALED CORTICOSTEROIDS IN SEVERE ASTHMA
C Rutherford, M Price, P Lindsay [P120]

TWELVE MONTH HEALTH OUTCOME FOLLOW-UP OF ASTHMA PRESENTATIONS TO A PUBLIC HOSPITAL USING SF-36.
A Thornton, C Partridge, G Wood, R Antic [P121]

IMPACT OF A SHORT COURSE FOR HEALTH PROFESSIONALS ON KNOWLEDGE , SKILLS AND ROLE IN ASTHMA EDUCATION
J Hazell, K Luttrell, KA Shaw, A Davis, M Lemcke, R Paton, L Sharota, J L Francis [P122]

TRAINED HEALTH WORKERS WHO ARE ACTIVELY INVOLVED IN ASTHMA EDUCATION HAVE HIGH ASTHMA MANAGEMENT KNOWLEDGE.
FA Whitehead, AP James, MJ Abramson, EH Walters [P123]

CAN KNOWLEDGE OF SELF MANAGEMENT OF ASTHMA IN ADOLESCENT BE ALTERED?
H Mamoon, S Shah, R Henry, A Bauman, P Gibson [P124]

BENEFITS OF AN ASTHMA EDUCATION PROGRAMME IN SECONDARY SCHOOL
R Henry, P Gibson, G Vimpani, L Francis [P125]

PEAK FLOW IS LESS VARIABLE DURING ASTHMA EXACERBATIONS ASSOCIATED WITH RESPIRATORY INFECTIONS THAN DURING A PERIOD OF POOR ASTHMA CONTROL
HK Reddel, SI Ware, GB Marks, CR Jenkins, AJ Woolcock [P126]

DIFFERENT PATTERNS OF AIRWAY INFLAMMATION DURING ASTHMA EXACERBATION: A CONTROLLED DOSE-REDUCTION STUDY
PG Gibson, AJ Wilson, JH Wlodarczyk, K Fakes, MJ Hensley [P127]

THE ROLE OF INDUCED SPUTUM EOSINOPHILS IN THE ASSESSMENT OF ASTHMA AND CHRONIC COUGH
P Wark, PG Gibson, K Fakes [P128]

ARE TESTS HELPFUL IN MANAGEMENT OF ASTHMATIC PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT?
J Burdon, M Loder, J Santamaria [P129]

SHOULD PERSISTENT COUGH IN CHILDREN BE LABELLED AS ASTHMA?
AO Faniran, J Rimmer, PG Gibson, JK Peat, AJ Woolcock . [P130]

DUST MITE ALLERGEN LEVELS, VENTILATION AND VISIBLE MOULD PREDICT INDOOR FUNGAL EXPOSURE
M Bailey, S Dharmage, J Raven, A Cheng, T Mitakakis, D Guest, J Rolland, F Thien, M Abramson, EH Walters [P131]

INDOOR ALLERGEN EXPOSURES ARE NOT RELATED TO ASTHMA IN ATOPIC ADULTS
E Walters, M Bailey, S Dharmage, J Raven, A Cheng, T Mitakakis, D Guest, J Rolland, F Thien, M Abramson [P132]

DER [P1]ACCUMULATION RATE ON SYNTHETIC AND FEATHER PILLOWS
N Rains, R Siebers, J Crane, P Fitzharris [P133]

SENSITIVITY TO FUNGAL ALLERGENS IS A RISK FACTOR FOR SEVERE ATTACKS OF ASTHMA
PN Black, A Udy, SM Brodie [P134]

SKIN TEST RESPONSE IN OCCUPATIONAL ALLERGY TO T1998 Annual Scientific MeetingANIAN BLACKWOOD
GL Kaufman [P135]

A RELIABLE AND VALID HOME VISIT REPORT FOR STUDIES OF ASTHMA
S Dharmage, M Bailey, J Raven, A Cheng,T Mitakakis, D Guest, J Rolland, F Thien, M Abramson, E Walters [P136]

VALIDATION OF A FOOD ALLERGY QUESTIONNAIRE (FAQ) ON ALCOHOLIC BEVERAGE-INDUCED ASTHMA
H Vally, N de Klerk, P Thompson [P137]

EVIDENCE FOR THE INCREASE, SINCE 1987, OF ALLERGIC DISEASES IN WESTERN CIVILISATION WITH SPECIAL REFERENCE TO THE HOUSE DUST MITE
PSClarke [P138]

A COMPARISON OF OBSERVED HOSPITAL ADMISSION RATES FOR ASTHMA WITH SELF-REPORTED ADMISSION RATES DERIVED FROM THE SOUTH AUSTRALIAN HEALTH OMNIBUS SURVEYS
R Ruffin, K McCaul, M Wakefield [P139]

READMISSION FOR ASTHMA AND SOCIOECONOMIC STATUS ASSOCIATION NON-SIGNIFICANT
A Heard, RE Ruffin, DA Campbell, P Gluyas [P140].

PERSONAL COPING STYLES PREDICT CHANGES IN QUALITY OF LIFE OF ASTHMA PATIENTS
R Adams, R Ruffin, B Smith [P141]

CASE-CONTROL STUDY OF SEVERE LIFE-THREATENING ASTHMA (SLTA) IN ADULTS: PSYCHOLOGICAL FACTORS
J Kolbe, W Fergusson, M Vamos, J Garrett [P142]

REDUCING ELECTROSTATIC CHARGE ON A PLASTIC SPACER BY USE OF DETERGENT GREATLY IMPROVES LUNG DEPOSITION
F Piérart, J Wildhaber, I Vrancken, S Devadason, P Le Souëf [P143]

ASTHMA: PHARMACOTHERAPY

HIGH DOSE INHALED STEROIDS AND BRUISING
C.Jenkins on behalf of a Collaborative Research Group of the Australian Lung Foundation [P144]

HALF THE DAILY DOSE OF NEW CFC-FREE FORMULATION STEROID ACHIEVES EQUIVALENT PULMONARY FUNCTION IN MODERATE ASTHMA
G Gross, P Chervinsky, J Ramsdell, J Vanden Burgt [P145]

50 MCG TWICE DAILY OF EXTRAFINE HFA-BECLOMETHASONE DIPROPIONATE AEROSOL IMPROVES ASTHMA CONTROL IN ADULT PATIENTS
F Hampel, E Lisberg, J Vanden Burgt, C Henon, P Stampone [P146]

THREE MONTH POST-MARKETING SURVEILLANCE STUDY COMPARING HFA-134A SALBUTAMOL SULPHATE METERED DOSE INHALER (MDI) WITH CFC SALBUTAMOL MDI IN U.K.GENERAL PRACTICE
JG Ayres, C Frost, WF Holmes, R Williams, SM Ward [P147]

IMPROVEMENT IN PULMONARY FUNCTION IN MODERATE ASTHMATICS WITH 400 MCG BECLOMETHASONE DIPROPIONATE (BDP) FROM A NEW CFC-FREE MDI
H Matthys, G Kunkel, S Hader [P148]

PULMONARY FUNCTION IN MODERATELY SEVERE ASTHMA CONTROLLED AT A SIGNIFICANTLY LOWER TOTAL DAILY DOSE OF STEROID FROM NEW CFC­FREE INHALER
R Davies, B O'Connor, D Donnell, P Stampone [P149]

COMPARISON OF A BREATH-ACTIVATED MDI TO COORDINATED AND DISCOORDINATED TECHNIQUE WITH PRESS & BREATHE HFA-BECLOMETHASONE MDIS
CL Leach, P Davidson, R Boudreau [P150]

CFC-FREE BECLOMETHASONE (BDP) AEROSOL HAS IMPROVED THERAPEUTIC RATIO
AJ Fairfax, D Donnell, W Song [P151]

HFA-BECLOMETHASONE PROVIDES EQUIVALENT LUNG DEPOSITION WITH OR WITHOUT ADD-ON SPACERS
CL Leach, P Davidson, R Boudreau [P152]

CHRONIC AIRFLOW OBSTRUCTION

INFLUENCE OF LOAD PERCEPTION ON THE REGULATION OF RESPIRATORY DRIVE
DM Smallwood, S Jack, L Ramondetta, M Kazins, T Demis, MCF Pain [P153]

AIRWAY VASCULAR CHANGES IN LUNG ALLOGRAFT RECIPIENTS
L Zheng, B E Orsida, C Ward, JW Wilson, TJ Williams, EH Walters, GI Snell [P154]

SECRETORY LEUCOCYTE PROTEINASE INHIBITOR IS AN IMPORTANT PROTECTIVE ANTIPROTEINASE IN THE LUNGS OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
M Ayad, KR Knight, S Brenton, JGW Burdon [P155]

SWALLOWING DYSFUNCTION MAY CONTRIBUTE TO RECURRENT BRONCHIAL INFECTION AND EXACERBATIONS OF CHRONIC AIRFLOW LIMITATION (CAL)
K Reid, J Maclean, M Kaatzke-McDonald, K Garvey, T Anderso, M J Peters [P156]

PRESENCE AND SEVERITY OF SWALLOWING DISORDERS IN PATIENTS WITH ACUTE VERSUS STABLE CHRONIC AIRFLOW LIMITATION (CAL).
J Maclean, A Winkworth, M Dodd, K Reid, M Peters. [P157]

SUSTAINED - RELEASE MORPHINE IS NOT AN EFFECTIVE TREATMENT FOR PATIENTS WITH BREATHLESSNESS DUE TO CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
P Poole, A Veale, P Black [P158]

DO NOT RESUSCITATE ORDERS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS IN AN AUSTRALIAN TEACHING HOSPITAL RESPIRATORY UNIT
M Sutherland, C McDonald [P159]

IMPROVING THE HOSPITAL-BASED MANAGEMENT OF HOME OXYGEN THERAPY
NA Heron, JR Wheatley [P160]

SPIROMETRY IN GENERAL PRACTICE:QUALITY ASSURANCE AND THE ROLE OF FORMAL TRAINING
T Eaton, S Withy, JE Garrett, J Mercer, RML Whitlock, HH Rea [P161]

CLINICAL

FACTORS AFFECTING THE OUTCOME OF AMIODARONE LUNG INJURY: A LITERATURE REVIEW
P Wark, L Olson, N Saltos [P162]

AMOEBIC ABSCESS OF LEFT LUNG
CM Mukerjee, GL Kaufman, W Wong [P163]

LONG-TERM GLUCOCORTICOID THERAPY PLACES MALES AT INCREASED RISK OF FUTURE OSTEOPOROSIS AND HIP FRACTURE
G Phillipov, PJ Phillips, B Smith [P164]

FACTORS INFLUENCING LIKELIHOOD OF RECEIVING LUNG TRANSPLANTATION IN NEWCASTLE UPON TYNE
E Gabbay, N Wrightson, G Parry, L Holt, PA Corris JH Dark [P165]

POST TRANSPLANT LYMPHOPROLIFERATIVE DISEASE (PTLD) IN HEART AND LUNG TRANSPLANT RECIPIENTS IN NEWCASTLE UPON TYNE
E Gabbay, G Tsang, G Parry, L Jalini, D Parums, PA Corris, JH Dark [P166]

FERROUS SULPHATE TABLET ASPIRATION; PRESENTATION AND COMPLICATIONS
ASC Scroop, P Finucane, D Henderson, P Frith [P167]

1230 - 1330 hrs LUNCH, Exhibition Hall

SIG BUSINESS MEETINGS Venues to be announced

1330 - 1500 HRSCONCURRENT SESSIONS

Sym 11 Master Clinician Session: Adult Hall B

Chair:Richard Ruffin - The Queen Elizabeth Hospital, SA

Martin Phillips - The Queen Elizabeth II Medical Centre, WA

Neil Douglas - Respiratory and Sleep Medicine, University of Edinburgh, UK

Charles Mitchell - Princess Alexandra Hospital, QLD

Jeff Garett - Green Lane Hospital, NZ

Douglas Henderson - Pathology Department, Flinders Medical Centre, SA

Phillip Costello - Radiology Department, The Queen Elizabeth Hospital, SA

Sym 12 Master Clinician Session: Paediatric Hall C

Chair:Rima Staugas - Adelaide Women's and Children's Hospital, SA

James Martin - Adelaide Women's and Children's Hospital, SA

Colin Robertson - Royal Children's Hospital, VIC

Steven Stick - Princes Margaret Hospital, WA

Lloyd Morris - Radiology Department, Adelaide Women's and Children's Hospital, SA

Roger Byard - Pathology Department, Adelaide Women's and Children's Hospital, SA

Sym13 Symposium: Muscle function in respiratory patients Meeting Room 1

Objectives:

• To discuss the developing area of research which has particular implications to the cause of disability and potential therapeutic interventions in patients with severe lung diseases
• Key papers in the published literature will be the basis for the presentations but research in progress will also be presented

Chair:Trevor Williams - Lung Transplant Service , Alfred Hospital, VIC

1330 Introduction
Trevor Williams

1332 Exercise testing in severe lung disease
Idelle Weisman - Director, Department of Clinical Investigation, William Beaumont Army Medical Centre, USA

1354 Skeletal muscle physiology and mechanism of fatigue
Michael McKenna - Senior Lecturer, Department of Physical Education and Recreation, Victorian University of Technology, VIC

1416 Peripheral skeletal muscle abnormalities and the effects of lung transplantation
Judy Morton - Research Fellow, Department of Respiratory Medicine, Alfred Hospital, VIC

1438 Potential aetiologies of skeletal muscle abnormalities and possible therapeutic approaches
Trevor Williams

Sym 14 Cell Biology SIG Symposium: Animal Models of Airways Disease Meeting Room 2

Objectives:

• To describe currently available models of airways disease
• To compare the pathophysiology of these models with human asthma
• To increase the understanding of the pathogenesis of human asthma

Chair:Raffaele Scicchitano - Department of Thoracic Medicine, Royal Adelaide Hospital, SA

1330 Good and better models of asthma
John Wilson - Department of Respiratory Medicine, Alfred Hospital, VIC

1348 The role of interleukin-5 and eotaxin in regulating airways eosinophilia: Implications for understanding asthma
Paul Foster - Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, ACT

1406 Susceptibility to inflammation, airways obstruction and hyperreactivity in murine models of asthma
Lindsay Dent - Department Microbiology and Immunology, University of Adelaide, SA

1424 Dissecting the molecular pathogenesis of asthma using genetically altered mice
Gary Anderson - Department of Pharmacology, University of Melbourne, VIC

1442 Airway function in a large animal model of bronchial hyperresponsiveness
Debra J Turner - Department of Physiology, University of Western Australia, WA

Oral 10 Population Health SIG: Oral presentations Meeting Room 3

Chair:Guy Marks - Royal Prince Alfred Hospital, NSW

1330 BREASTFEEDING AND ITS RELATIONSHIP TO WHEEZING OUTCOMES IN CHILDREN AT AGE FIVE
W Oddy, F Stanley, L Landau, P Burton [O55]

1345 COST EFFECTIVENESS OF OUTPATIENT TREATMENT OF DEEP VENOUS THROMBOSIS WITH LOW MOLECULAR WEIGHT HEPARIN
T Howe, B Smith, M Hopps, D Brown, L Mykyta, R Ruffin [O56]

1400 ASSOCIATIONS BETWEEN WHITE BLOOD CELL COUNT, LUNG FUNCTION,RESPIRATORY ILLNESS AND MORTALITY: THE BUSSELTON STUDY
AL James, MW Knuiman, ML Divitini, AW Musk, G Ryan, HC Bartholomew [O57]

1415 THE PREVALENCE OF CIGARETTE SMOKING AND SMOKING CESSATION RATES IN A HOSPITAL POPULATION
R Wood-Baker [O58]

1430 SMOKING CESSATION PROGRAMME FOR HOSPITAL EMPLOYEES
TE Jones, A M Southcott, RE Ruffin [O59]

1445 A DECADE OF TUBERCULOSIS CONTROL IN SA
R Antic, K van Roekel, RA Stapledon, AT Thornton, K Kirke [O60]

1500 COFFEE Foyer 1

1530 CLOSING CEREMONY Hall B

Poster Award

TSANZ / Australian Lung Foundation John Read Prize for Physiological Research

Respiratory Nurses Awards